Algorithms for quality of service provisioning and enhancement in optical burst switched networks

Ph.DDOCTOR OF PHILOSOPH

A Machine Learning-based Approach to Vietnamese Handwritten Medical Record Recognition

Handwritten text recognition has been an active research topic within computer vision division. Existing deep-learning solutions are practical; however, recognizing Vietnamese handwriting has shown to be a challenge with the presence of extra six distinctive tonal symbols and extra vowels. Vietnam is a developing country with a population of approximately 100 million, but has only focused on digitalization transforms in recent years, and so Vietnam has a significant number of physical documents, that need to be digitized. This digitalization transform is urgent when considering the public health sector, in which medical records are mostly still in hand-written form and still are growing rapidly in number. Digitization would not only help current public health management but also allow preparation and management in future public health emergencies. Enabling the digitalization of old physical records will allow efficient and precise care, especially in emergency units. We proposed a solution to Vietnamese text recognition that is combined into an end-to-end document-digitalization system. We do so by performing segmentation to word-level and then leveraging an artificial neural network consisting of both convolutional neural network (CNN) and a long short-term memory recurrent neural network (LSTM) to propagate the sequence information. From the experiment with the records written by 12 doctors, we have obtained encouraging results of 6.47% and 19.14% of CER and WER respectively

Economic impact of climate change on agriculture: a case of Vietnam

Food security, agricultural exports, and livelihoods have improved by rapid agricultural expansion in the previous 30 years. In the coming decades, warming trends and human pressures are expected to exacerbate the impact of climate change on agriculture. A time series of data from 1990 to 2020 examines the economic effects of climate change on Vietnamese farm production. After using the Augmented Dickey-Fuller and Philips-Perron unit root tests, the ARDL bounds testing technique estimates short and long-run cointegration. They found long-run cointegration between the variables. A positive influence of CO2 emissions is identified, although negative impacts of average temperature and rainfall are found. But only in the short term can energy consumption benefit agriculture. Non-climatic factors like crop production and fertiliser consumption have beneficial short- and long-term impacts on agriculture production and yield. Juselius Jhansen As well as proving long-term cointegration between variables. The report advises the Vietnamese government to create and implement many adaptation programmes to preserve the agriculture industry from climate change.Nguyen Van Huong (Faculty of Economics, Hung Yen University of Technology and Education (UTEHY)), Bui Thi Minh Nguyet (Vietnam National University of Forestry), Hoang Van Hung (Faculty of Economics, Hung Yen University of Technology and Education (UTEHY)), Hoang Minh Duc (Faculty of Economics, Hung Yen University of Technology and Education (UTEHY)), Nguyen Van Chuong (University of Financial and Business Administration (UFBA)), Do Minh Tri (Nguyen Van Linh Political School), Phung Van Hien (National Academy of Public Administration (NAPA))Includes bibliographical references

Vietnam geographical exploitation under the United Nations Convention on the Law of the Sea in 1982 (UNCLOS 1982)

As an active member of the United Nations Convention on the Law of the Sea - UNCLOS, Vietnam has completed 3 Reports on the Limits of the Continental Shelf and has submitted two of them to the Commission on the Limits of the Continental Shelf - CLCS, before the deadline 13-5-2009. Those are: (1) Outer Limits of the Vietnam’s Extended Continental Shelf: North Area (VNM-N); (2) Outer Limits of the Vietnam’s Extended Continental Shelf: Middle Area (VNM-M) and (3) Vietnam - Malaysia Joint Continental Shelf Submission. The VNM-M has not yet been submitted but it was mentioned to the CLCS and will be submitted in the appropriate time.Vietnam’s submissions were highly appreciated by CLCS; although the CLCS has not yet organized a special sub-committee to look at our reports, the secretariat of CLCS has already posted the executive reports of our submissions, with our principle claims on the continental shelf, on the website of the CLCS since May 2009. This paper presents shortly the UNCLOS and its application in Vietnam case

A modern purification by accelerated solvent extraction and centrifugal partition chromatography and biological evaluation of capsaicin from Capsicum chinense

A special alkaloid compound known as capsaicin, which can only be found in the fruit of the Capsicum plant, was isolated and tested for its anti-inflammatory activity. The purpose of this work is to establish a simple and quick approach for capsaicin purification utilizing centrifugal partition chromatography (CPC) as well as an effective method - accelerated solvent extraction (ASE), for extracting capsaicin from Capsicum chinense. After purification, capsaicin was validated by HPLC-DAD at 281 nm to be > 90% purity. The in vivo anti-inflammatory activity of the isolated capsaicin was also investigated, and the IC50 value of the capsaicin was determined to be 57.61 µg/mL. The current work emphasizes how an ASE and CPC system may combine to extract high-purity capsaicin from Capsicum chinense, which have the anti-inflammatory activity, as we evaluated in the experiment

Quantifying antimicrobial access and usage for paediatric diarrhoeal disease in an urban community setting in Asia.

OBJECTIVES: Antimicrobial-resistant infections are a major global health issue. Ease of antimicrobial access in developing countries is proposed to be a key driver of the antimicrobial resistance (AMR) epidemic despite a lack of community antimicrobial usage data. METHODS: Using a mixed-methods approach (geospatial mapping, simulated clients, healthcare utilization, longitudinal cohort) we assessed antimicrobial access in the community and quantified antimicrobial usage for childhood diarrhoea in an urban Vietnamese setting. RESULTS: The study area had a pharmacy density of 15.7 pharmacies/km2 (a pharmacy for every 1316 people). Using a simulated client method at pharmacies within the area, we found that 8% (3/37) and 22% (8/37) of outlets sold antimicrobials for paediatric watery and mucoid diarrhoea, respectively. However, despite ease of pharmacy access, the majority of caregivers would choose to take their child to a healthcare facility, with 81% (319/396) and 88% (347/396) of responders selecting a specialized hospital as one of their top three preferences when seeking treatment for watery and mucoid diarrhoea, respectively. We calculated that at least 19% (2688/14427) of diarrhoea episodes in those aged 1 to <5 years would receive an antimicrobial annually; however, antimicrobial usage was almost 10 times greater in hospitals than in the community. CONCLUSIONS: Our data question the impact of community antimicrobial usage on AMR and highlight the need for better education and guidelines for all professionals with the authority to prescribe antimicrobials

HIV-Associated TB in An Giang Province, Vietnam, 2001–2004: Epidemiology and TB Treatment Outcomes

BACKGROUND: Mortality is high in HIV-infected TB patients, but few studies from Southeast Asia have documented the benefits of interventions, such as co-trimoxazole (CTX), in reducing mortality during TB treatment. To help guide policy in Vietnam, we studied the epidemiology of HIV-associated TB in one province and examined factors associated with outcomes, including the impact of CTX use. METHODOLOGY/PRINCIPAL FINDINGS: We retrospectively abstracted data for all HIV-infected persons diagnosed with TB from 2001-2004 in An Giang, a province in southern Vietnam in which TB patients receive HIV counseling and testing. We used standard WHO definitions to classify TB treatment outcomes. We conducted multivariate analysis to identify risk factors for the composite outcome of death, default, or treatment failure during TB treatment. From 2001-2004, 637 HIV-infected TB patients were diagnosed in An Giang. Of these, 501 (79%) were male, 321 (50%) were aged 25-34 years, and the most common self-reported HIV risk factor was sex with a commercial sex worker in 221 (35%). TB was classified as smear-positive in 531 (83%). During TB treatment, 167 (26%) patients died, 9 (1%) defaulted, and 6 (1%) failed treatment. Of 454 patients who took CTX, 116 (26%) had an unsuccessful outcome compared with 33 (70%) of 47 patients who did not take CTX (relative risk, 0.4; 95% confidence interval [CI], 0.3-0.5). Adjusting for male sex, rural residence, TB smear status and disease location, and the occurrence of adverse events during TB treatment in multivariate analysis, the benefit of CTX persisted (adjusted odds ratio for unsuccessful outcome 0.1; CI, 0.1-0.3). CONCLUSIONS/SIGNIFICANCE: In An Giang, Vietnam, HIV-associated TB was associated with poor TB treatment outcomes. Outcomes were significantly better in those taking CTX. This finding suggests that Vietnam should consider applying WHO recommendations to prescribe CTX to all HIV-infected TB patients

A Multi-Center Randomised Controlled Trial of Gatifloxacin versus Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adults in Vietnam

BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing. OBJECTIVES: We performed a randomised controlled trial to compare the efficacy and safety of gatifloxacin (10 mg/kg/day) versus azithromycin (20 mg/kg/day) as a once daily oral dose for 7 days for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. METHODS: An open-label multi-centre randomised trial with pre-specified per protocol analysis and intention to treat analysis was conducted. The primary outcome was fever clearance time, the secondary outcome was overall treatment failure (clinical or microbiological failure, development of typhoid fever-related complications, relapse or faecal carriage of S. typhi). PRINCIPAL FINDINGS: We enrolled 358 children and adults with suspected typhoid fever. There was no death in the study. 287 patients had blood culture confirmed typhoid fever, 145 patients received gatifloxacin and 142 patients received azithromycin. The median FCT was 106 hours in both treatment arms (95% Confidence Interval [CI]; 94-118 hours for gatifloxacin versus 88-112 hours for azithromycin), (logrank test p = 0.984, HR [95% CI] = 1.0 [0.80-1.26]). Overall treatment failure occurred in 13/145 (9%) patients in the gatifloxacin group and 13/140 (9.3%) patients in the azithromycin group, (logrank test p = 0.854, HR [95% CI] = 0.93 [0.43-2.0]). 96% (254/263) of the Salmonella enterica serovar Typhi isolates were resistant to nalidixic acid and 58% (153/263) were multidrug resistant. CONCLUSIONS: Both antibiotics showed an excellent efficacy and safety profile. Both gatifloxacin and azithromycin can be recommended for the treatment of typhoid fever particularly in regions with high rates of multidrug and nalidixic acid resistance. The cost of a 7-day treatment course of gatifloxacin is approximately one third of the cost of azithromycin in Vietnam. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN67946944

An Outbreak of Severe Infections with Community-Acquired MRSA Carrying the Panton-Valentine Leukocidin Following Vaccination

Background: Infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination. Methods and Findings: We carried out a field investigation after adverse events following immunization (AEFI) were reported. We reviewed the clinical data from all cases. S. aureus recovered from skin infections and from nasal and throat swabs were analyzed by pulse-field gel electrophoresis, multi locus sequence typing, PCR and microarray. In May 2006, nine children presented with AEFI, ranging from fatal toxic shock syndrome, necrotizing soft tissue infection, purulent abscesses, to fever with rash. All had received a vaccination injection in different health centres in one District of Ho Chi Minh City. Eight children had been vaccinated by the same health care worker (HCW). Deficiencies in vaccine quality, storage practices, or preparation and delivery were not found. Infection control practices were insufficient. CA-MRSA was cultured in four children and from nasal and throat swabs from the HCW. Strains from children and HCW were indistinguishable. All carried the Panton-Valentine leukocidine (PVL), the staphylococcal enterotoxin B gene, the gene complex for staphylococcal-cassette-chromosome mec type V, and were sequence type 59. Strain HCM3A is epidemiologically unrelated to a strain of ST59 prevalent in the USA, althoughthey belong to the same lineage. Conclusions. We describe an outbreak of infections with CA-MRSA in children, transmitted by an asymptomatic colonized HCW during immunization injection. Consistent adherence to injection practice guidelines is needed to prevent CA-MRSA transmission in both in- and outpatient settings